Four pillars of heart failure: contemporary ... - Open Heart
Mar 2, 2021 — The past two decades have heralded dramatic improvements in outcomes for people living with heart failure with reduced ejection fraction (HFrEF). 1 The more widespread implementation of disease modifying pharmacological therapies,2 supported by landmark trials of renin-angiotensin system inhibitors3 and beta-blockers4 have improved longevity despite a background of an ageing and increasingly ...
Vitamin K2—a neglected player in cardiovascular health: a …
Vitamin K2 serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. In its inactive form, this protein is associated with various markers of cardiovascular disease including …
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Open Heart is dedicated to publishing high quality, peer reviewed medical research in all disciplines and therapeutic areas of cardiovascular medicine. Research is published across all study phases and designs, from protocols to phase I trials to meta-analyses, including small or specialist studies. Opinionated discussions on controversial ...
Cardiogenic shock: evolving definitions and future directions in ...
May 8, 2019 — Cardiogenic shock (CS) is a complex and highly morbid entity conceptualised as a vicious cycle of injury, cardiac and systemic decompensation, and further injury and decompensation. The pathophysiology of CS is incompletely understood but limited clinical trial experience suggests that early and robust support of the failing heart to allow for restoration of systemic homoeostasis appears ...
On-X versus St Jude Medical Regent mechanical aortic valve …
Feb 23, 2017 — Objective We aimed to compare the early haemodynamic data of the On-X and St Jude Medical (SJM) Regent bileaflet mechanical prostheses in the aortic position.Methods A retrospective study was performed using data collected prospectively for a national database. Thirty-three patients who had aortic On-X valve (On-X group) and 33 matched patients who had aortic SJM Regent valve (SJM group) were ...
Long-term survival after coronary bypass surgery and …
Oct 24, 2016 — Abstract. Objectives To assess whether there exists a long-term difference in survival after treatment with coronary bypass surgery or percutaneous coronary intervention in patients with coronary disease as judged by all-cause mortality. Methods Retrospective study from the Feiring Heart Clinic database of survival in 22 880 patients—15 078 ...
Associations between short-term exposure to PM - Open Heart
Objective Short-term ambient fine particulate matter (PM 2.5) is associated with adverse cardiovascular events including myocardial infarction (MI). However, few studies have examined associations between PM2.5 and subclinical cardiomyocyte damage outside of overt cardiovascular events. Here we evaluate the impact of daily PM2.5 on cardiac troponin I, a cardiomyocyte specific biomarker of ...
Coronary artery ectasia: prevalence, angiographic characteristics …
Apr 6, 2020 — Objective Determine coronary artery ectasia (CAE) prevalence and clinical outcome in a large cohort of patients underwent coronary angiography.Methods In an 11-year period, between 2006 and 2017, 20 455 coronary angiography studies were performed at a large university centre. Patients diagnosed with CAE based on procedure report were included in the final analysis.Results CAE was diagnosed in ...
Therefore, magnesium supplementa-tion may have significant cardioprotective effects. Second, magnesium activates the Na–K–ATPase, which may be inhibited by non-glucose fuels such as lactate and free fatty acid in the setting of ischaemia. Third, deficiency in magnesium may also lead to chronic electrical instability.
Acute myocarditis caused by COVID-19 disease and following …
Mar 9, 2022 — COVID-19 postvaccination myocarditis. To end the COVID-19 pandemic, vaccination is an essential component of the public health strategy. Large, randomised controlled trials of COVID-19 vaccines were found safe and effective in preventing laboratory-confirmed symptomatic COVID-1924–26; even though, adverse effects have been reported.In the specific group population of young adults and ...