The San Francisco 49ers certainly have had some bad luck so far this season and are dealing with some high-profile injuries.

San Francisco 49ers star tight end George Kittle missed his second straight practice on Friday as ESPN insider Adam Schefter ...

The rookie, who has made all his field goals and extra points in two games, injured his groin during last weekend’s loss to ...

When the Rams take on the 49ers in Week 3, star wide receiver Cooper Kupp won't be joining his teammates on the field.

Week 3 matchup vs. Rams with key injuries to McCaffrey, Samuel, and Kittle, testing their depth in this crucial NFC West ...

Aaron Donald retired this offseason and suddenly the Rams defense can't stop anybody. It's missing starting cornerback ...

Los Angeles Rams offensive coordinator Mike LaFleur explained the benefits of having ex-San Francisco 49ers QB Jimmy ...

Two NFC West teams renew their rivalry as the San Francisco 49ers visit the Los Angeles Rams. It is time to continue our NFL ...

Herbert injured his right leg in the third quarter of Week 2’s 26-3 win against the Carolina Panthers trying to escape the ...

Like for many other head coaches and offensive coordinators across the NFL facing the Los Angeles Rams, life has gotten a lot easier on San Francisco 49ers head ...

Rams receivers step up to fill void left by injured stars Kupp and Nacua, embracing collective effort for upcoming 49ers game ...

NFL teams grapple with mounting injuries, forcing them to rely on backups and adapt strategies as the season progresses.