DNA, the genetic material compacted in chromosomes, stores information to regulate all the cell processes in the body. Two decades ago, in addition to the widely known Watson-Crick double helix model ...
IN 1962, when David R. Davies was in his 30s, he and two coworkers at the National Institutes of Health proposed that short, guanine-rich stretches of DNA could assume unusual structures. On the basis ...
As an important non-canonical DNA secondary structure in vivo and in vitro, G-quadruplexes (GQs) have been widely investigated in many fields including biology, medicinal chemistry, supramolecular ...
Compounds that stabilize G-quadruplex structures in telomeric DNA block telomerase activity and may be potentially valuable as antitumor drugs. Figure 1: Guanine-rich telomeric DNA adopts several ...
Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...
Figure 1. Schematic illustration of the spontaneous Hoogsteen pairing-based strand displacement reaction between one homo-dimolecular GQ target and dual G-rich invading probes at room temperature, ...
Most women with ovarian cancer respond very well to chemotherapy at first – but in 70% of cases the cancer grows back. And although many patients will respond to chemotherapy a second or third time, ...
There is no more iconic image in biology than that of DNA's double-stranded helix, which coils and supercoils on itself to form dense chromosomes. But a quite different, square-shaped type of DNA ...
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