The increasing interest in Bayesian group sequential design is due to its potential to reinforce efficiency in clinical trials, shorten drug development time, and enhance the accuracy of statistical ...

In clinical trials with sequential patient entry, fixed sample size designs are unjustified on ethical grounds and sequential designs are often impracticable. One solution is a group sequential design ...

To control the Type I error probability in a group sequential procedure using the logrank test, it is important to know the information times (fractions) at the times ...

Decline in the use of erythropoiesis-stimulating agents: Long-term effects of regulation, reimbursement, and unfavorable data. Effect of a topoisomerase-1 inhibitor (topotecan) on the efficacy of ...

Bioequivalence studies are an essential component in the development and approval of generic pharmaceutical products, ensuring that they perform similarly to their reference counterparts. These ...